Effects of Dietary Intervention and Simvastatin on Plasma Nitric Oxide in Patients with Hyperlipidemia
2004
Yim, J.E. (Kyung Hee University, Seoul, Republic of Korea) | Park, C.S. (Inha University, Inchon, Republic of Korea) | Choue, R.W. (Kyung Hee University, Seoul, Republic of Korea) | Cha, Y.N. (Inha University, Inchon, Republic of Korea) | Chyun, Jonghee (Inha University, Inchon, Republic of Korea)
Dietary intervention and simvastatin is beneficial in the prevention cardiovascular diseases by lowering plasma lipid levels. Endothelial dysfunction is associated with coronary artery disease and its risk factors and is reversed by dietary intervention. It has been suggested that hyperlipidemia contributes to the development of atherosclerosis by increasing inducible nitric oxide synthase (iNOS) expression via intimal thickening.
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