Broadspectrim, a novel antibacterial from Streptomyces sp.
2004
Bonjar, G.H.S.,Bahonar Univ. of Kerman (Iran). Dept. of Plant Pathology)Fooladi, M.H
Rapid emergence of antibacterial resistance is well documented as aserious problem worldwide. This situation shows that the potencies ofprevalent antibiotics are decreasing steadily. This situation implies the needfor searching new antimicrobials to replace with invalidated ones or use inantibiotic rotation programs. In a four years study, from 1,300 soilActinomycete isolates collected from different localities of Kerman, Hormozgan,Sistan and Baloochestan, south and south east Provinces of Iran, Streptomycessp. isolate No. 419 showed widest antibacterial activity. The active principlenamed as Broadspectrim. It showed antibacterial activity against wide range ofG+ and G- bacteria as Bacillus anthracis, Bacillus subtilis, Citrobacterdiversus, Citrobacter freundii, Corynebacterium diphtheriae, Enterobacter sp.,Escherichia coli, Klebsiella pneumoniae, Micrococcus luteum, Proteus vulgaris,Proteus rettgeri, Proteus mirabilis, Proteus morganii, Pseudomonas fluorescens,Pseudomonas aeruginosa, Pseudomonas syringae pv syringae, Salmonella ParaTyphi A, B, C, D, Salmonella typhi, Sarcinia sp., S. marcescens, Shigelladysentery, S. flexneri, S. sonnei, Staphylococcus aureus, Staphylococcusepidermidis, Streptococcus pneumoniae, Vibrio cholera Eltor (INABA) andXanthomonas sp. but Shigella flexneri and Staphylococcus albus were resistantto it.
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