Involvement of calcineurin and PKB/Akt in development of hereditary hypertension
Hong, Y.G.(University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA) | Cho, J.H.(University of Alabama at Birmingham, Birmingham, AL, USA) | Kim, J.H.(Gyeongsang National University, Jinju, Republic of Korea)E-mail:joohkim@nongae.gsnu.ac.kr
Severe hypertension (greater than 180 mmHg) develops in spontaneously hypertensive rats (SHR) after 12 wk-oldhowever, it is not clear whether what kinds of molecular mechanism leads to altered cardiac performance following developmental stages in SHR. Also, although the effect of calcineurin (Cn) to promote cardiomyocyte hypertrophy in vivo and in vitro is established, its overall necessity as a hypertrophic mediator is currently an area of ongoing debate. Thus, we have examined i) body weight and blood pressure, ii) differences of expression and distribution of signaling molecules such as Cn, protein kinase B/Akt (PKB/Akt), and extracellular signal-regulated kinase (ERK) between SHR and their agematched control Wistar-Kyoto (WKY) rats following developmental stages.
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