Single dose toxicity study of CKD-602, a new camptothecin anticancer agent, in Beagle dogs
Kim, J.C.;Shin, D.H.(Chonnam National University, Gwangju, Republic of Korea) | Park, S.C.(Kyungpook National University, Daegu, Republic of Korea) | Son, W.C.(Huntingdon Life Science, Huntingdon, UK) | Cha, S.W.;Han, J.H.;Bae, J.H.;Suh, J.E.;Chung, M.K.(Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea)
The present study was carried out to investigate the potential acute toxicity of CKD-602 by a single intravenous dose in Beagle dogs. The test chemical was administered intravenously to male and female Beagle dogs at dose levels of 0.3, 0.5, or 2.5 mg/kg. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. All males and females of the 2.5 mg/kg dose group were found dead between the fourth and seventh day after the injection.
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