Comparative pharmacokinetics of norfloxacin-glycine acetate after single oral administration and medication with drinking water in broilers
Lim, J.H.;Lim, B.Y.;Park, B.K.;Kim, M.S.;Jang, B.S.;Yun, H.I.(Chungnam National University, Daejeon, Republic of Korea)E-mail:hiyun@cnu.ac.kr | Park, S.C.(Kyungpook National University, Daegu, Republic of Korea)
Norfloxacin (NFX) is a fluorquinolone antibacterial agent with a high antimicrobial activity and might have great potential for treating common infections in poultry. The objective of this study was to obtain comparative pharmacokinetic data after a single oral administration and medication with drinking water of norfloxacin-glycine acetate (NFX-GA) at the dose rate of 10 mg/kg bw in broilers. Fifty minutes following oral administration of NFX-GA, serum concentrations peaked at 1.32 ㎍/mL (range 1.03-1.45 ㎍/mL).
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