Analysis of premature death of Sprague-Dawley rats in carcinogenicity studies
Son, W.C.(Huntingdon Life Sciences, Huntingdon, UK) | Kim, B.H.(Amorepacific RnD Center, Yongin, Republic of Korea)E-mail:bhkim@amorepacific.com
To help the interpretation of causes of death, it is critical that the background incidence of factors contributing to death be recorded and archived. Information was gathered from the control groups of 19 rat carcinogenicity studies. All cases of death occurring within the 2-year period were reviewed. Out of 1124 males and 1084 females, 720 male (64.1%) and 689 female (63.6%) decedents were recorded. There was no difference in the probability of survival between two sexes. Analysis of factors contributing to death revealed that 400 males (48.7%) had neoplastic changes, 189 males (23.0%) had non-neoplastic lesions, and 232 males (28.3%) died from unknown causes.
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