Coexpression of PCNA and p21 for DNA repair in small intestinal crypt cells of mouse with ∨60Co γ-rays irradiation
2005
Hong, S.J. (Cheju National University, Jeju, Republic of Korea) | Hwang, I.S. (Cheju National University, Jeju, Republic of Korea) | Ahn, M.J. (Cheju National University, Jeju, Republic of Korea) | Shin, T.K. (Cheju National University, Jeju, Republic of Korea) | Joo, H.G. (Cheju National University, Jeju, Republic of Korea) | Park, H.J. (Cheju National University, Jeju, Republic of Korea) | Jee, Y.H. (Cheju National University, Jeju, Republic of Korea), E-mail: yhjee@cheju.ac.kr
The irradiation of radioactive γ-ray induces apoptosis of radiosensitive organs for homeostasis. In this study, we investigated the repair mechanisms for homeostasis in the small intestine after cell damage by ∨60Co γ-ray irradiation. The apoptosis was most frequently observed in the crypt cells of the small intestine after four and six hours by radioactive γ-ray irradiation, and the frequency of apoptosis was proportional to the amount of irradiation. Also, the number of apototic cells was coincident with expression pattern of p53.
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