Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene in Coronary Artery Disease in Southern Turkey
2005
Acarturk, Esmeray (Cukurova University, Adana, Turkey), E-mail: kanarya@cu.edu.tr | Attila, Gulen (Cukurova University, Adana, Turkey) | Bozkurt, Abdi (Cukurova University, Adana, Turkey) | Akpmar, Onur (Cukurova University, Adana, Turkey) | Matyar, Selcuk (Cukurova University, Adana, Turkey) | Seydaoglu, Gulsah (Cukurova University, Adana, Turkey)
Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean 54.3±9.8 years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %).
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