Induction of Quinone Reductase, an Anticarcinogenic Marker Enzyme, by Extract from Chrysanthemum zawadskii var. latilobum K.
2005
Kim, J.R. (Kyungpook National University, Daegu, Republic of Korea) | Kim, J.H. (Kyungpook National University, Daegu, Republic of Korea) | Lim, H.A. (Kyungpook National University, Daegu, Republic of Korea) | Jang, C.H. (Kyungpook National University, Daegu, Republic of Korea) | Kim, J.H. (Kyungpook National University, Daegu, Republic of Korea) | Kwon, C.S. (Andong National University, Andong, Republic of Korea) | Kim, Y.K. (Kookmin University, Seoul, Republic of Korea) | Kim, J.S. (Kyungpook National University, Daegu, Republic of Korea), E-mail: vision@knu.ac.kr
Induction of NAD(P)H:(quinone-acceptor) oxidoreductase (QR) which promotes obligatory two electron reduction of quinones and prevents their participation in oxidative cycling and thereby the depletion of intracellular glutathione, has been used as a marker for chemopreventive agents. Induction of phase Ⅱ enzyme is considered to be an important mechanism of cancer prevention. In our previous study, we assessed the quinone reductase QR-inducing activities of 216 kinds of medicinal herb extracts in cultured murine hepatoma cells, BPRc1 and hepalc1c7 cells. Among the 216 herbal extracts tested in that study, extracts from Chrysanthemum zawadskii showed significant induction of QR.
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