Bioactive compounds from coral-reef invertebrates
1997
Bonnington, Lea | Tanaka, Junichi | Higa, Tatsuo(University of the Ryukyus, Okinawa (Japan). Dept. of Chemistry, Biology, and Marine Science)
Since the 1970s a number of chemically and biologically interesting compounds have been discovered from marine sponges, tunicates, coelenterates, and other invertebrates. Some of them, such as an anticancer agent bryostatin-1, are now in the clinical trials, and some are used as important tools in biochemical research. Coral reefs in the tropical and subtropical waters are particularly rich in the sources of bioactive substances. In our search for antitumor and antiviral compounds from the coral-reef organisms of the Western Pacific, we have found a variety of active compounds. Our most recent examples include highly cytotoxic macrolides such as zampanolide (1), macrocyclic alkaloids, and cyclic peptides from sponges. Here we present the isolation, structures, and activities of some selected compounds discovered recently in our laboratory.
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