Efficacy Study of Activation on Macrophage in Germanium-fortified Yeast
2005
Lee, S.H. (GerantiPharm. Ltd., Seoul, Republic of Korea), E-mail: gepharm@gerantiusa.com | Rho, S.N. (Chung-Ang University, Ansung, Republic of Korea) | Sohn, T.U. (GerantiPharm. Ltd., Seoul, Republic of Korea)
The aim of this study was to evaluate an efficacy about activation on macrophage, using model that measured cell viability, nitric oxide (NO), iNOS (inducible nitric oxide synthase) expression and tumor necrosis factor-α (TNF-α) on Raw 264.7 cells following treatment of Germanium-fortified Yeast in 0, 5, 10, 25, 50, 100, 200 ㎍/ml and the same concentration of dried yeast without germanium. Cell viability (%) and NO produced in activated-macrophage were dose-dependant, a significant increase of the cell viability (132.5%) and NO in 10 ㎍/ml (p less than 0.05).
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