Residue of oxytetracycline hydrochloride and alkyl trimethyl ammonium calcium oxytetracycline in the muscle and mid-gut of Perciforms or Pleuronectiformes fish species and kuruma prawn
2007
Watanabe, K.(National Research Inst. of Aquaculture, Otsuki, Kochi (Japan)) | Nishioka, T. | Imaizumi, H. | Sakiyama, K. | Yamada, T. | Ohta, K. | Suzuki, S. | Hotta, T. | Iida, T.
This study examined twelve fish or shrimp species: the sea bass Lateolabrax japonicus, the Pacific mackerel Scomber japonicus, the horse mackerel Scomber australasicus, the bluefin tuna Thunnus thynnus, the skipjack Trachurus japonica, the striped jack Pseudocaranx dentex, the Japanese parrot fish Oplegnathus fasciatus, the Japanese flounder Paralichthys olivaceus, the marble sole Pleuronectes yokohamae, the barfin flounder Verasper moseri, the spotted halibut Verasper variegatus, and the kuruma prawn Penaeus japonicus. These fishes and shrimp were fed raw fish or dry pellet containing 50 mg/kg (BW) of oxytetracycline hydrochloride (OTC) of alkyl trimethyl ammonium calcium oxytetracycline (OTC-Q) for seven days (prescription period). Thereafter, feeds containing no antibiotic were provided to these fishes and shrimp continuously for 20 or 40 days (OTC-Q Perciforms or Pleuronectiformes fishes) and 30, 40 or 25 days (OTC Perciforms fishes, Pleuronectiformes fishes or shrimp) (resting period). The muscles of these fishes and shrimp were individually sampled and stored at -80 deg C until analysis. The mid-gut of shrimp was also sampled and stored. Sampling was conducted the day after the prescription and the resting periods. Residue of these specimens as oxytetracycline was analyzed using high-performance liquid chromatography. Specimens which were sampled after prescription showed high concentrations of OTC. However, rested specimens showed values lower than those set under food safety standards for human consumption.
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