Effect of ethanol-induced p42/44 MAPkinase activity on IGF system in primary cultured rat hepatocytes
2006
Lee, S.M. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, J.H. (Chonbuk National University, Jeonju, Republic of Korea) | Kang, C.W. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: cwkang@chonbuk.ac.kr
Ethanol abuse is associated with liver injury, neurotoxicity, modulation of immune responses, and increased risk for cancer, whereas moderate ethanol consumption exerts protective effects against liver injury. However, the underlying signal transduction mechanisms of insulin-like growth factors (IGFs) which play an important regulatory role in various metabolism mechanisms are not well understood. We investigated the effects of ethanol-induced p42/44 activity on IGF-I secretion, IGF-I receptor and IGFBP-1 secretion using radioimmunoassay and western blotting in primary cultured rat hepatocytes.
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