Functional characterization of P∧2x/P∧2Y receptor in isolated swine renal artery
2007
Kim, J.H. (Gyeongsang National University, Jinju, Republic of Korea) | Jeon, J.C. (Gyeongsang National University, Jinju, Republic of Korea) | Lee, S.K. (Gyeongsang National University, Jinju, Republic of Korea) | Lee, S.J. (Inje University, Gimhae, Republic of Korea) | Lee, Y.G. (Inje University, Gimhae, Republic of Korea) | Won, J.Y. (Inje University, Gimhae, Republic of Korea) | Kang, J.S. (Inje University, Gimhae, Republic of Korea) | Hong, Y.G. (Inje University, Gimhae, Republic of Korea), E-mail: yonghong@inje.ac.kr
To understand the role of P∧2x/P∧2Y receptor in cortex region of kidney and renal artery, molecular and functional analysis of P∧2x/P∧2Y receptor by pharmacophysiological skill in conventional swine tissues were performed. In functional analysis of P∧2Y receptor for vascular relaxation, 2-methylthio adenosine triphosphate, a strong agonist of P∧2Y receptor, induced relaxation of noradrenaline (NA)-precontracted renal artery in a dose-dependent manner. Strikingly, relaxative effect of ATP, 2-msATP, agonists of P∧2Y receptor, abolished by treatment of reactive blue 2, a putative P∧2Y receptor antagonist.
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