Inhibitory Effects of Sasa borealis Leaves Extracts on Carbohydrate Digestive Enzymes and Postprandial Hyperglycemia
2007
Hwang, J.Y. (Pusan National University, Busan, Republic of Korea) | Han, J.S. (Pusan National University, Busan, Republic of Korea), E-mail: hanjs@pusan.ac.kr
This study was designed to investigate whether Sasa borealis leaves extracts (SLE) may inhibit yeast α-glucosidase and α-amylase activities and postprandial hyperglycemia in STZ-induced diabetic mice. Freeze-dried SLE was extracted with 70% methanol and followed by a sequential fractionation with dicholoromethan, ethylacetate, butanol, and water. Both ethylacetate and butanol fractions showed high inhibitory activities against the α-glucosidase and α-amylase enzymes. The IC∧50 of ethylacetate and butanol fractions against α-glucosidase were 0.54 and 0.63 mg/mL, respectively, indicating a greater inhibition effect than acarbose (0.68 mg/mL) (p less than 0.05).
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