Ulva lactuca Fucoidan Extract and its Protective Effects on CCl₄-induced Liver Dysfunction
2007
Nam, C.S. (Silla University, Busan, Republic of Korea) | Kang, K.S. (Silla University, Busan, Republic of Korea) | Ha, B.J. (Silla University, Busan, Republic of Korea), E-mail: [email protected]
The effects of Fucoidan extracted from Ulva lactuca on carbon tetrachloride (CCl₄)-induced dysfunction in CCl₄-posttreated rats were investigated. Ulva lactuca fucoidan (ULF) of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1 ml/kg for 14 days. On the day 15, 3.3 mg/kg of CCl₄ dissolved in olive oil (1 : 1) was injected 12 hours before anesthetization. We examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) in serum of rats, superoxide dismutase (SOD) in mitochondrial fraction and catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) in liver of rats. SOD, CAT, GPx decreased, and GOT, GPT, MDA increased in the CCl₄-treated group.
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