Effects of SNPs in Haptoglobin on Average Daily Gain in Pig
2008
Kim, M.J. (National Institute of Animal Science, RDA, Suwon, Republic of Korea) | Chung, H.Y. (National Institute of Animal Science, RDA, Suwon, Republic of Korea), E-mail: [email protected] | Cho, K.H. (National Institute of Animal Science, RDA, Seungwhan, Republic of Korea) | Jeon, G.J. (National Institute of Animal Science, RDA, Seungwhan, Republic of Korea) | Kim, J.H. (National Institute of Animal Science, RDA, Suwon, Republic of Korea)
In order to provide information of genetic variants for Haptoglobin (Hp) gene, which may be related to weight traits in pig, a total of 235 animals from National Institute of Animal Science (NIAS) were screened with 3 primers. The primer sequences were selected using the porcine cDNA sequences based on NM_214000, and the exon boundaries were estimated. Genetic variants were observed using direct sequencing analysis, and there were 9 SNPs detected at nucleotide positions 503 (A/G), 509 (A/G), 709 (C/T), 734 (C/A), 742 (G/A), 769 (A/G), 840 (C/T), 876 (C/T) and 882 (C/A). All the SNPs were located in coding regions, and mutations caused amino acid changes at nucleotide positions 503, 509, 734, 742 and 769. Allele frequencies of SNPs were estimated for all segments. The SNPs at nucleotide position 509 (p less than 0.0001) and 734 (p less than 0.05) were significantly associated with average daily gain, but no significance was observed with other SNPs. From the results, the identified SNPs may be a useful candidate marker for the porcine weight gain traits.
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