A T-cell type multicentric lymphoma affecting central nervous system in a Cocker Spaniel dog
2008
Kim, J.W. (Konkuk University, Seoul, Republic of Korea) | Jung, D.I. (Konkuk University, Seoul, Republic of Korea) | Kang, B.T. (Konkuk University, Seoul, Republic of Korea) | Yoo, J.H. (Konkuk University, Seoul, Republic of Korea) | Park, C. (University of California, Davis, California, USA) | Kim, D.Y. (University of Missouri-Columbia, Columbia, USA) | Park, H.M. (Konkuk University, Seoul, Republic of Korea), E-mail: parkhee@konkuk.ac.kr
A 4-year-old female Cocker spaniel was presented with respiratory distress and abdominal distension. Pleural effusion, ascites, hepatosplenomegaly, and superficial lymphadenopathy were observed and multicentric lymphoma was diagnosed by cytological examination. Immunophenotyping of lymph node and bone marrow using polymerase chain reaction for antigen receptor rearrangement identified a stage V lymphoma origination from T-cell. Despite of systemic chemotherapy using L-asparagenase, vincristine, cyclophoaphamide and prednisolone, neurologic deficits came out and progressed. Cerebrospinal fluid analysis revealed neoplastic lymphocytic pleocytosis indicating central nervous system involvement of lymphoma. The postmortem diagnosis was confirmed based on the histology and imunohistochemistry.
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