Histopathological effect of experimental feeding of melamine and cyanuric acid in kidney of crucian carp (Carassius carassius)
2010
Wang, S.J., Chungbuk National University, Cheongju, Republic of Korea | Heo, G.J., Chungbuk National University, Cheongju, Republic of Korea
Melamine is an organic base and a trimer of cyanamide which contains 66% nitrogen by mass, but it was sometimes illegally added to food products in order to enhance the apparent protein content for the bigger profit. Many Chinese infants and pet animals fed melamine-containing formulas suffered acute kidney failure with renal crystal formation. Fish feeds were also recently found to be contaminated with melamine. This experiment has been designed to determine whether renal crystals can be experimentally induced in crucian carp (Carassius carassius) fed melamine and cyanuric acid (each at 400 mg/kg/day for 3 days) in combination, and to compare experimentally induced crystals with those from pet animals with triazine related renal failure. The results showed that all fish developed gold brown renal crystals arranged in radial spherulites in the renal tubules, similar to those detected in the pet animals.
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