Nitrogenase structure, function, and genetics.
1993
Burgess B.K.
This paper is an overview of what is currently known about the structure and biosynthesis of the two component proteins of Mo nitrogenase. It focuses initially on the Fe protein polypeptide, the assembly of the holoprotein, its three dimensional structure, the properties of its [4Fe-4S] cluster and the effects of MgATP/MgADP binding. This is followed by a consideration of the MoFe protein polypeptides, the properties of the "P" clusters, the assembly of the FeMo-co deficient MoFe protein, the physical properties and biosynthesis of FeMo-cofactor and the organization of the holoprotein. The flow of electrons from reductant, to the Fe protein, to the MoFe protein, to substrate, is then considered with emphasis on the role of ATP and the reduction of the physiological substrates N2 and H(+). Nitrogen fixation (nif) genes are mentioned throughout this discussion and their organization is summarized. The vanadium and "Fe-only" nitrogenase systems are also briefly discussed.
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Эту запись предоставил Wolters Kluwer
