Rapid Voltammetric Identification and Determinationof Simvastatin at Trace Levels in Pharmaceuticalsand Biological Fluid
2008
Nigović, Biljana | Faculty of Pharmacy | Biochemistry, University of Zagreb, Zagreb, Croatia | biljana@pharma.hr | Komorsky-Lovrić, Šebojka | Center for Marine | Environmental Research, Ruđer Bošković Institute, Zagreb, Croatia | Devčić, Dubravka | Faculty of Pharmacy | Biochemistry, University of Zagreb, Zagreb, Croatia
Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutarylcoenzymeA reductase. The reduction behavior of drug has been studied in different supportingelectrolytes within the pH range 3–9. Based on the adsorptive character of simvastatin onto themercury electrode surface, a new cathodic square-wave stripping voltammetry method for itsdirect determination at trace levels has been proposed. The voltammetric response could beused to determine drug concentration in the range 1.0 × 10–8 to 7.5 × 10–7 mol L–1, with detectionlimit of 4.5 × 10–9 mol L–1. Applicability to biological fluid analysis was illustrated. Themethod was successfully employed, without sample pretreatment, for quantitation of the activeingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapididentification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphiteelectrode has been examined.
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