Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber
2011
Hung, Tran Manh, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam | Thuong, Phuong Thien, National Institute of Medicinal Materials, Hanoi, Vietnam | Nhan, Nguyen Trung, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam | Thanh Mai, Nguyen Thi, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam | Quan, Tran Le, University of Natural Science, National University Hochiminh city, Hochiminh, Vietnam | Choi, J.S., Pukyong National University, Busan, Republic of Korea | Woo, M.H., Catholic University of Daegu, Gyungsan, Republic of Korea | Min, B.S., Catholic University of Daegu, Gyungsan, Republic of Korea | Bae, K.H., Chungnam National University, Daejeon, Republic of Korea
Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC∧50 values ranging from 10.2±0.5 μM to 24.5±1.6 μM, meanwhile, compound 14 - 17 exhibited strong inhibitory activity with IC∧50 values from 2.1±0.2 to 5.5±0.3 μM. Compounds 14 - 17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.
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