In vitro inhibitory activity of Bifidobacterium and a Lactobacillus strains agains Candida albicans

Denkova, R., Sofia University "St. Kliment Okhridski", Sofia; Yanakieva, V., University of Food Technology, Plovdiv; Denkova, Z., University of Food Technology, Plovdiv; Nikolova, V., University of Food Technology, Plovdiv; Radeva, V., University of Food Technology, Plovdiv

In vitro inhibitory activity of Bifidobacterium and a Lactobacillus strains agains Candida albicans

2013

Denkova, R., Sofia University "St. Kliment Okhridski", Sofia (Bulgaria) | Yanakieva, V., University of Food Technology, Plovdiv (Bulgaria) | Denkova, Z., University of Food Technology, Plovdiv (Bulgaria) | Nikolova, V., University of Food Technology, Plovdiv (Bulgaria) | Radeva, V., University of Food Technology, Plovdiv (Bulgaria)

One of the requirements to probiotic cultures is to exhibit high antimicrobial activity against pathogenic microorganisms. The aim of this work was to determine the degree of suppression of Candida albicans by strains lactobacilli and bifidobacteria of human origin. Тhe antifungal activity of four strains of lactobacilli and bifidobacteria of human origin – Lactobacillus acidophilus A2, Lactobacillus acidophilus Ac, Lactobacillus delbrueckii ssp. bulgaricus GB and Bifidobacterium bifidum sp. 4 – against Candida albicans NBIMCC 74 by co-cultivation under static conditions at 37°C in skimmed milk was studied. Despite the high concentration of viable cells of lactobacilli or bifidobacteria, all four strains restrained the growth of the pathogen - biostatic action and by the 72nd hour of co-cultivation the pathogen retained high concentration of viable cells. The measured high titratable acidity during the co-cultivation of lactobacilli or bifidobacteria and the pathogen did not affect the growth of the pathogen. The performed studies are of potential importance in the treatment of candidiasis in humans and animals. The tested strains are a primary basis for the creation of probiotics for the treatment of these serious diseases.

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