Influence of vaccine potency and booster administration of foot-and-mouth disease vaccines on the antibody response in calves with maternal antibodies
2017
Can cokcalIskan, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Tuncer Turkoglu, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Ergun Uzunlu, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Beyhan Sareyyupoglu, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Ibrahim HancI, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Ahmet Ipek, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Abdullah Arslan, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Ayca Babak, Directorate-General for Agriculture and Rural Development, Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Gulnur Ildeniz, Directorate-General for State Farms, Ministry of Food, Agriculture and Livestock, Ankara, Turkey | Veli Gulyaz, Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara, Turkey
Foot-and-mouth disease is one of the most important viral diseases of cloven-hoofed animals. Mass vaccination is an effective method to control the disease and is frequently utilized in endemic regions. Sufficient protection of young animals is important in mass vaccination campaigns. Maternal antibodies negatively affect the success of vaccination. Hence, determination of the optimal vaccination age is crucial for the uninterrupted protection of young animals. This study was performed to identify the effect of vaccine potency and booster administration on serum neutralizing antibody titers of calves with different levels of maternal antibodies. Calves (n = 111) on a state farm were used in this study. Oil adjuvant foot-and-mouth disease vaccines with 3 PD50 and 6 PD50 potencies were used with or without booster administration. Serum samples were collected each month up to day 120 postvaccination. Virus neutralization tests were used to measure the serum neutralizing antibody titers and estimate the protection period by using pre-determined cut-off values for protection. The results revealed that a vaccination with a 6 PD50 potency vaccine, preferably followed by a booster dose, should be used to overcome maternal immunity for incessant protection.
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