Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue
2017
Ahn, H., Kookmin University, Seoul, Republic of Korea | Go, G.W., Kookmin University, Seoul, Republic of Korea
PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-weekold male C57BL/6 mice were fed normal chow (18% kcal from fat) or a HFD (60% kcal from fat). HFD-fed animals were also subjected to PineXol treatment at a dose of 10 or 50 mg/kg body weight (BW) (PX10 or PX50, respectively) body weight. The body weight and body fat mass in the PX50 group were statistically lower than those in the HFD group (p less than 0.05 and p less than 0.001, respectively). The concentration of hepatic triglycerides, total cholesterol, and lowdensity lipoprotein cholesterol were reduced in the PX50 group compared with the HFD group (p less than 0.01). Acetyl CoA carboxylase (p less than 0.01), elongase of very long chain fatty acids 6 (p less than 0.01), stearoyl CoA desaturase 1 (p less than 0.05), microsomal triglyceride transfer protein (p less than 0.01), and sterol regulatory element-binding protein 1 (p less than 0.05) were significantly decreased in the PX50 group compared with that in the HFD group. In white adipose tissue, CCAATenhancer-binding protein alpha (p less than 0.05), peroxisome proliferator-activated receptor gamma (p less than 0.001), and perilipin (p less than 0.01) were decreased in the PX50 group compared with those in the HFD group. Therefore, the current study implies the potential of PineXol for the prevention and/or amelioration of obesity, in part by inhibition of both hepatic lipid synthesis and adipogenesis in white adipose tissue.
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