TnpPred: A Web Service for the Robust Prediction of  Prokaryotic Transposases

Riadi, Gonzalo; Medina-Moenne, Cristobal; Holmes, David S.

TnpPred: A Web Service for the Robust Prediction of Prokaryotic Transposases

2012

Riadi, Gonzalo(Center for Bioinformatics and Genome Biology, Fundación Ciencia para la Vida Y Facultad de Ciencias Biologicas) | Medina-Moenne, Cristobal(Centro de Bioinformática y Simulación Molecular, Universidad de Talca) | Holmes, David S.(Center for Bioinformatics and Genome Biology, Fundación Ciencia para la Vida Y Facultad de Ciencias Biologicas)

Transposases (Tnps) are enzymes that participate in the movement of insertion sequences (ISs) within and between genomes. Genesthat encode Tnps are amongst the most abundant and widely distributed genes in nature. However, they are difficult topredict bioinformatically and given the increasing availability of prokaryotic genomes and metagenomes, it is incumbent to developrapid, high quality automatic annotation of ISs. This need prompted us to develop a web service, termed TnpPred for Tnpdiscovery. It provides better sensitivity and specificity for Tnp predictions than given by currently available programs asdetermined by ROC analysis. TnpPred should be useful for improving genome annotation. The TnpPred web service is freely available fornoncommercial use.

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