Diamine oxidase supplementation improves symptoms in patients with histamine intolerance
2019
Schnedl, W.J., Practice for General Internal Medicine, Bruck/Mur, Austria | Schenk, M., Das Kinderwunsch Institut Schenk GmbH, Dobl, Austria | Lackner, S., Medical University of Graz, Graz, Austria | Enko, D., General Hospital Steyr, Steyr, Austria | Mangge, H., Medical University of Graz, Graz, Austria | Forster, F., Sciotec Diagnostic Technology GmbH, Tulln, Austia
Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO. We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements.
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