Sesquiterpenoids from the Herb of Leonurus japonicus
Liang Xiong | Qin-Mei Zhou | Cheng Peng | Xiao-Fang Xie | Li Guo | Xiao-Hong Li | Juan Liu | Zhao-Hua Liu | Ou Dai
Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
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