Branched fatty acyl esters of hydroxyl fatty acids (FAHFAs), appealing beneficial endogenous fat against obesity and type-2 diabetes

Balas, Laurence; Coudray, Christine; Durand, Thierry

Branched fatty acyl esters of hydroxyl fatty acids (FAHFAs), appealing beneficial endogenous fat against obesity and type-2 diabetes

2018

Balas, Laurence | Coudray, Christine | Durand, Thierry

After a brief overview of the biological significance of FAHFAs, the present Minireview highlights the differentstrategies developed for their chemical syntheses. The term “FAHFAs” has been introduced in 2014 for fatty acyl esters of hydroxyl fatty acids, found in adipocytes, with antidiabetic properties. However, many other natural products contain this type of branched lipids in their structure. This review was then extended to the synthesis of these subunits, even though the length of the lipid chains and the location of the ester linkages are different, since the developed strategies may be applied to the synthesis of “FAHFA”.

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