Pain Management Using Nano-Bio Fusion Gel in Fixed Orthodontic Therapy-Induced Gingivitis: A Split-Mouth Design Study

Mohammad Khursheed Alam; Kiran Kumar Ganji; Alreshidi Meshari; Srinivas Munisekhar Manay; Nafij Bin Jamayet; Ammar A Siddiqui

Pain Management Using Nano-Bio Fusion Gel in Fixed Orthodontic Therapy-Induced Gingivitis: A Split-Mouth Design Study

Mohammad Khursheed Alam; Kiran Kumar Ganji; Alreshidi Meshari; Srinivas Munisekhar Manay; Nafij Bin Jamayet; Ammar A Siddiqui

Nanotechnology-based products containing antioxidants may be effective adjuvants in the treatment of periodontal diseases. To assess the treatment effect of nano bio-fusion gel (NBFG) in pain perception (PP) in fixed orthodontic therapy-induced gingivitis (FOTIG). The gel contains propolis, vitamin C, and vitamin E in the form of nanoemulsion. Thirty-two patients were finally selected from the orthodontic clinic after assessments for FOTIG. Patients were allocated randomly into active and placebo-control groups. Patients were evaluated at three intervals (T1, T2, and T3). Pain perception using a numeric rating scale (NRS) was performed at baseline (T1), on the 7th day (T2) and on the 28th day (T3) on his/her visit to an orthodontic clinic. In the T1, T2, and T3 period, patients apply NBFG (active or placebo side) to their gingiva after brushing two times a day for 28 consecutive days. Results: The baseline data between the active or placebo group showed almost similar PP. From T1 to T2 and T3, the active or placebo-control group showed significant improvement in PP over time. Compared to placebo, the active group showed highly significant (p &le: 0.001, T1 to T2 and T2 to T3) improvement in PP. The use of NBFG is an effective means of improvement in PP of FOTIG cases.

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