Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing

Xiwen Guan; Shuanping Zhao; Weixuan Xiang; Hai Jin; Ningbo Chen; Chuzhao Lei; Yutang Jia; Lei Xu

Genetic Diversity and Selective Signature in Dabieshan Cattle Revealed by Whole-Genome Resequencing

Xiwen Guan; Shuanping Zhao; Weixuan Xiang; Hai Jin; Ningbo Chen; Chuzhao Lei; Yutang Jia; Lei Xu

Dabieshan cattle are a typical breed of southern Chinese cattle that have the characteristics of muscularity, excellent meat quality and tolerance to temperature and humidity. Based on 148 whole-genome data, our analysis disclosed the ancestry components of Dabieshan cattle with Chinese indicine (0.857) and East Asian taurine (0.139). The Dabieshan genome demonstrated a higher genomic diversity compared with the other eight populations, supported by the observed nucleotide diversity, linkage disequilibrium decay and runs of homozygosity. The candidate genes were detected by a selective sweep, which might relate to the fertility (GPX5, GPX6), feed efficiency (SLC2A5), immune response (IGLL1, BOLA-DQA2, BOLA-DQB), heat resistance (DnaJC1, DnaJC13, HSPA4), fat deposition (MLLT10) and the coat color (ASIP). We also identified the &ldquo:East Asian taurine-like&rdquo: segments in Dabieshan cattle, which might contribute to meat quality traits. The results revealed by the unique and valuable genomic data can build a foundation for the genetic improvement and conservation of genetic resources for indigenous cattle breeds.

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