Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

Clodagh  P. O’Neill; Róisín  M. Dwyer

Nanoparticle-Based Delivery of Tumor Suppressor microRNA for Cancer Therapy

2020

Clodagh P. O’Neill | Róisín M. Dwyer

Improved understanding of microRNA expression and function in cancer has revealed a range of microRNAs that negatively regulate many oncogenic pathways, thus representing potent tumor suppressors. Therapeutic targeting of the expression of these microRNAs to the site of tumors and metastases provides a promising avenue for cancer therapy. To overcome challenges associated with microRNA degradation, transient expression and poor targeting, novel nanoparticles are being developed and employed to shield microRNAs for tumor-targeted delivery. This review focuses on studies describing a variety of both natural and synthetic nanoparticle delivery vehicles that have been engineered for tumor-targeted delivery of tumor suppressor microRNAs in vivo.

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