Innate Immune Response in SARS-CoV-2 Infection

Giovanna Schiuma; Silvia Beltrami; Daria Bortolotti; Sabrina Rizzo; Roberta Rizzo

Innate Immune Response in SARS-CoV-2 Infection

2022

Giovanna Schiuma | Silvia Beltrami | Daria Bortolotti | Sabrina Rizzo | Roberta Rizzo

An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell response in COVID-19 (Corona Virus Disease-19) patients or in their activation after vaccination against SARS-CoV-2, host innate immune response has raised even more interest as well. In fact, innate immunity, including Natural Killer (NK) cells, monocytes/macrophages and neutrophils, represent the first line of defense against the virus and it is essential to determine the correct activation of an efficient and specific acquired immune response. In this perspective, we will report an overview on the main findings concerning SARS-CoV-2 interaction with innate host immune system, in correlation with pathogenesis and viral immune escape mechanisms.

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