Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats
2019
Dina R. S. Gad El-Karim
The present study was designed to evaluate the probable ameliorativeeffect of dandelion extract against doxorubicin hemato-cardiotoxicity. Toaccomplish this study, four groups of male albino rats (n=7) were used asfollow, Group I: served as a control group, Group II: received dandelionextract (200 mg/ kg), Group III: received doxorubicin (2.5 mg/kg) and GroupIV: received dandelion extract and doxorubicin identically to groups II and III.Doxorubicin was administrated 3times/week for two consecutive weeks, whiledandelion extract was administrated daily for two consecutive weeks beforedoxorubicin administration and continued during doxorubicin treatment. Theresults illuminated that, administration of doxorubicin has a deleterious effecton both of blood cellular components and cardiac tissues, which was indicatedby significant pancytopenia (decrease in all blood cell types), elevated serumcardiac enzymes activity (CK-MB and LDH), increased serum level of cardiacrelated proteins (troponin I, atrial natriuretic peptide (ANP) and B-typenatriuretic peptide (BNP) with a depletion of cardiac tissues antioxidant (GSH,and SOD enzyme) and elevated lipid peroxide (MDA) level in this tissues. Coadministration of dandelion extract with doxorubicin significantly alleviated itshemato-cardiotoxic effect which was reflected positively on hematobiochemical changes and cardiac histopathological alterations.
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