Effect of Eimeria stiedae infestation on the immune response of rabbit vaccinated with oil adjuvant polyvalent rabbit Pasteurellosis
2010
Elham. A. Youssef | N. B. Eskander | Lilian. F. S. Melika | Amina A. El-Bayoumy | M. S. El-Nabarawy
In an attempt to evaluate the possible role of Eimeria stiedae infection on rabbit vaccinatedwith haemorrhagic septicaemia oil adjuvant vaccine, a total of 60 New-Zealand rabbits weredivided into 6 groups (A- F). The first four groups subdivided into two subgroups. The subgroups(A1, A2) vaccinated and infected at time of 1st dose of vaccine, subgroup (B1, B2) vaccinated andinfected at 2 weeks post 1st vaccination, subgroup (C1, C2) which vaccinated and infected at thetime of 2nd dose of vaccination, finally subgroup (D1, D2) vaccinated and infected at 2 weeks post2nd dose of vaccine. Group E vaccinated only but the group F left as non vaccinated non infected(control). The results revealed that E. stiedae infection at the time or after 2 weeks from first orsecond dose of vaccination (A1, B1, C1 and D1) and treated with semduramycine 150 showed slightdecrease of the antibody titer in contrast the untreated group (A2, B2, C2 and D2) showed suddendecrease of P. multocida antibody titer measured by indirect haemagglutination and ELISA test.Vaccinated group (E) was the superior one showing the highest antibody titer. The challenge test ofall rabbit groups with virulent P. multocida revealed a protective percent of 83.4%, 50%, 100%and 0 % in treated, untreated, vaccinated and control group respectively, but subgroups C2, D2the protective value was 33.4% this due to challenge concurrency post or at the time of infection.These findings reflect the important to avoid coccidial infection following vaccination programs toobtain better immune response to haemorrhagic septicaemia oil adjuvant pasteurellosis vaccineand high level of protection.
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