Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility
2019
Xin He | Jing Yang | Ling Qiu | Dan Feng | Feng Ju | Lu Tan | Yu-Zhi Li | Yu-Cheng Gu | Zhen Zhang | Da-Le Guo | Yun Deng
Three new thiodiketopiperazines (1&ndash:3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher ester analysis and calculated ECD spectra. Compound 4 and 5 have the activity to promote the gastrointestinal motility of zebrafish via acting on the cholinergic nervous system.
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