Study of impact of a 1,4-DHP derivative glutapyrone on DNA using in vitro tests
LeonovaĻeonova, Elīna, Elina | DislereDišlere, Kristīne, Kristine | Rostoka, Evita | Baumane, Larisa | Bisenieks, Egils | DubursDuburs, Gunārs, Gunars | Sjakste, Nikolajs
The goal of the study was to test the ability of a representative of the 1,4-DHP group — glutapy-rone to protect DNA against damage. The compound increased the concentration of the hydroxyl radicals produced in the Fenton reaction; it did not scavenge peroxynitrite and did not protect plasmid DNA against damage by products of the Fenton reaction. On the other hand, the com-pound protected HeLa cells against damage by peroxinitrite and B-lymphocytes against DNA damage in the conditions of oxidative stress induced by transfection of the Tat protein derived from the HIV virus. It is supposed that glutapyrone mobilises DNA repair systems.
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