Canine demodicosis treated with ivermectin
1985
Prayot Tanticharoenyos | Tipa Tanticharoenyos (Chulalongkorn Univ., Bangkok (Thailand). Inst. of Health Research)
One of the cutaneous parasitic diseases of canine was demodicosis caused by Demodex canis. The life cycle of this demodectic mite, which was present in the hair follicles of almost all dogs, was not well understood. Demodicosis was manifested in two very distinct and vastly different clinical forms: the localized or squamous form and the generalized or pustular form. Just as the prognosis and course of the localized and generalized forms of demodicosis differ vastly, so do the therapeutic measures. Most dogs with localized demodicosis recover in 3-8 weeks while the treatment of generalized demodicosis had in the past, been frustrating and inconsistent. Many drug trials had been used with little or no success, on generalized demodicosis. The ivermectin, one1126of the eight major avermectins, was produced by actinomycete, Streptomyces avermitilis. This novel macrocyclic lactone was a broad range antiparasitic agent of external as well as internal parasites by oral or parental dosing. The result from ivermectin studying of generalized demodicosis in canine, 400 mg/kg body wt. subcutaneously with 1 week interval for 2-3 times, showed clinical signs improvement o
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