Cis-regulatory sequences leading to female-specific expression of yolk protein genes 1 and 2 in the fat body of Drosophila melanogaster
1993
Abrahamsen, N. (Edinburgh Univ. (United Kingdom). Div. of Biological Sciences. Inst. of Cell and Molecular Biology. Developmental Biology Center Cell) | Martinez, A. | Kjaer, T. | Soendergaard, L. | Bownes, M.
The three yolk protein genes (yp) of Drosophila melanogaster are transcribed in a sex- and tissue-limited fashion. Cis-regulatory sequences were seached in regions flanking yp1 and yp2 to identify the elements that confer female-specific expression in the fat body. One such 127 bp element has previously been identified in this region. Two additional regions confer female fat bodyspecific expression on an Adh reporter gene and on the native yp2 gene, respectively. This suggests some redundancy in the regulation of expression of the yp genes. Computer searches for putative binding sites for the DSX protein, which regulates sex-specific expression of the yp genes, revealed several such sites in the constructs. However, the significance of these is unclear since many such sites also occur in genes which one would not expect to be regulated in a sex-specific manner (e.g. Adh, Actin 5C). DSX should act in concert with other proteins to mediate sex- and tissue-specific expression of the yp genes.
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