Cross-protective immunity and the serological classification system for Bacteroides nodosus [cause of footrot in sheep]
1991
Stewart, D.I. | Vaughan, J.A. | Burns, K.J. | Dufty, J.H. (Commonwealth Scientific and Industrial Research Organisation, Parkville (Australia). Div. of Animal Health) | Elleman, T.C. | Hoyne, P.A. (Commonwealth Scientific and Industrial Research Organisation, Parkville (Australia). Div. of Biomolecular Engineering)
The relationship between the serological classification system for serogroup B and for serogroup H of Bacteroides nodosus and cross-protection between subgroups within these serogroups was examined. Protection against footrot following vaccination was achieved against other subgroup strains provided sufficient cross-reactive antibody was induced by shared pilus antigens. Within serogroup B better cross-protection against one subgroup was obtained with a pili vaccine than a whole-cell vaccine that correlated with higher pilus antibody titres induced by the former. For serogroup H, a lack of cross-protection and serological reactivity between subgroups was demonstrated which indicates that the prototype strain of subgroup H2 should be designated a new serogroup.
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