Antioxidant and Histopathological Effect of Galantamine Against Paracetamol-Induced Side Effect

Gamal  Shams; Shahd  El-Mesiry

Antioxidant and Histopathological Effect of Galantamine Against Paracetamol-Induced Side Effect

2022

Gamal Shams | Shahd El-Mesiry

The goal of this research was to find out more about the possible protective role of galantamine (GAL) (0.3 mg/kg P.O) for 28 successive days against paracetamol (PCM) toxicity that was administrated on day 29 of the experiment, at day 30, blood sample were collected for evaluation of antioxidant enzymes and tissues for histopathological studies. Oxidative stress biomarkers which included serum superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde and histopathological studies indicated that GAL has protective effects by prohibiting the improvement in oxidative stress biomarkers and improved the histopathological lesions seen in livers and kidneys in vivo model against hepatic and renal toxicity induced by PCM in rats.

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