Biomarkers of Oxidative Stress and Some Immunological Disturbance Induced by Deltamethrin and Diazinon on Fattening Buffaloes Calves
2023
Seif E. Salem | Eman I. M. Ismail | Halla A. El Said | Halla M. Khalil | Marwa M. Sarhan | Mona Salah El Deen
The present study was carried out to evaluate oxidative stress and some immunological parameters of deltamethrin and diazinon in fattening buffalos’ calves. A total of 15 healthy calves, 8-12 months of age were divided into 3 groups (5 in each). Gp (1) control, Gp (2) calves sprayed with 1ml deltamethrin/liter water 3 times one week apart and Gp (3) calves sprayed with 1ml diazinon/liter water 3 times one week apart. On the 1st, 15th, and 30th-day post spraying 3 blood samples were taken from control and tested calves for determination of some immunohistochemical. Deltamethrin or diazinon each alone induced significant elevation in WBCs, neutrophils, eosinophils, MDA, AST, ALT, ALP, LDH, CK, total lipid, triglycerides, cholesterol, urea, and creatinine associated with a significant reduction on phagocytic %, phagocytic index, killing %, serum IgG, IgM, IgA, total protein, albumin, α, β, γ globulin, total globulin, A/G ratio, CAT, SOD, GSH and GSH-px beside insignificant decrease in lymphocyte, monocyte and basophils at 1st and 15th days post spraying. All biochemical parameters improved after 30 days post-spraying as compared with the control. It was concluded that deltamethrin and diazinon induce some adverse effects in leukogram biochemical parameters and have immunosuppressive effects in calves.
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