Fast and reliable generation of [¹⁸F]triflyl fluoride, a gaseous [¹⁸F]fluoride source

Pees, A.; Sewing, C.; Vosjan, M. J. W. D.; Tadino, V.; Herscheid, J. D. M.; Windhorst, A. D.; Vugts, D. J.

Fast and reliable generation of [¹⁸F]triflyl fluoride, a gaseous [¹⁸F]fluoride source

2018

A novel strategy for the production of reactive [¹⁸F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [¹⁸F]triflyl fluoride is formed instantaneously at room temperature from hydrated [¹⁸F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [¹⁸F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [¹⁸F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [¹⁸F]fluoroestradiol ([¹⁸F]FES) and O-2-[¹⁸F]fluoroethyl-l-tyrosine ([¹⁸F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol⁻¹.

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