A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves

Amen, Yhiya M.; Marzouk, Amani M.; Zaghloul, Mona G.; Afifi, Mohamed S.

A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves

2015

Amen, Yhiya M. | Marzouk, Amani M. | Zaghloul, Mona G. | Afifi, Mohamed S.

A new acylated kaempferol glycoside, kaempferol 3- O -α- l -rhamnopyranosyl-(1 → 6)- O -[β- d -glucopyranosyl-(1 → 2)-4- O -acetyl-α- l -rhamnopyranosyl-(1 → 2)]-β- d -galactopyranoside, has been isolated from the leaves of Tipuana tipu (Benth.) Lillo growing in Egypt, along with three known flavonol glycosides, kaempferol 3- O- rutinoside, quercetin 3- O- rutinoside (rutin) and kaempferol 3- O- [α - l -rhamnopyranosyl-(1 → 6)]-[α - l -rhamnopyranosyl-(1 → 2] - β - d -glucopyranoside. Structure elucidation was achieved through different spectroscopic methods. Structure relationship with anti-inflammatory activity using carrageenin-induced rat paw oedema model is discussed.

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