Copper-Mediated Oxidative Cross-Coupling Reaction of Terminal Alkynes with α-Silyldifluoromethylphosphonates: An Efficient Method for α,α-Difluoropropargylphosphonates

Jiang, Xueliang; Chu, Lingling; Qing, Feng-Ling

Copper-Mediated Oxidative Cross-Coupling Reaction of Terminal Alkynes with α-Silyldifluoromethylphosphonates: An Efficient Method for α,α-Difluoropropargylphosphonates

2012

Jiang, Xueliang | Chu, Lingling | Qing, Feng-Ling

A copper-mediated oxidative cross-coupling reaction of terminal alkynes with readily available α-silyldifluoromethylphosphonates under mild conditions has been developed. This method allows for an efficient synthesis of a series of synthetically useful α,α-difluoropropargylphosphonates with excellent functional group compatibility.

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