Trichothecene biosynthesis in Gibberella pulicaris: inheritance of C-8 hydroxylation

Beremand, M.N.; Desjardins, A.E.

Trichothecene biosynthesis in Gibberella pulicaris: inheritance of C-8 hydroxylation

1988

Beremand, M.N. | Desjardins, A.E.

Naturally occurring strains of Gibberella pulicaris (Fusarium sambucinum) produce different kinds and levels of trichothecene toxins. Progery from crosses between strains which produce trichothecenes with an oxygen-containing group at C-8 (C8+) and those that do not (C8-) can segregate in a 1:1 ratio for this trait. These results define a genetic locus, which we have designated Tox1. The segregation patterns observed for progeny obtained from crosses between high-toxin producers and low-toxin producers indicate that the level of toxin production is determined by several loci. One gene which controls quantitative aspects of toxin production segregates independently of both the Tox1 locus and another locus which controls toxin levels. These results suggest that multiple, unlinked nuclear loci are involved in the control of trichothecene biosynthesis.

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