Effect of Plasma Lipoproteins and Their Complexes with Polysaccharides on Interleukin-1β Concentration in Macrophages of Mice with HA-1 Ascitic Hepatoma
2009
Polyakov, L. M | Sumenkova, D. V | Panin, L. E
Experiments on cultured peritoneal macrophage from mice with HA-1 ascitic hepatoma showed that plasma lipoproteins present in the incubation medium decreased intracellular concentration of interleukin-1β. These changes were most pronounced for high-density lipoproteins (alone or in combination with cortisol). Bacterial and yeast polysaccharides had little effect on interleukin-1β concentration in macrophages. Addition of polysaccharides in combination with lipoproteins was followed by a 2-3-fold decrease in interleukin-1β concentration. A combination of polysaccharides and high-density lipoproteins had the strongest effect. These properties of plasma lipoproteins should be taken into account in the correction of macrophage function during tumor growth.
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