Adverse effects of short-term personal exposure to fine particulate matter on the lung function of patients with chronic obstructive pulmonary disease and asthma: a longitudinal panel study in Beijing, China
2021
Duan, Ruirui | Niu, Hongtao | Yu, Tao | Huang, Ke | Cui, Han | Chen, Chen | Yang, Ting | Wang, Chen
Fine particulate matter (PM₂.₅) is an important environmental factor affecting human health. However, most studies on PM₂.₅ and health have used data from fixed monitoring sites to assess PM₂.₅ exposure, which may have introduced misleading information on the exposure–response relationship. We aimed to assess the effect of short-term personal PM₂.₅ exposure on lung function in patients with chronic obstructive pulmonary disease (COPD) and asthma. To achieve this, we conducted a longitudinal panel study among 37 COPD patients and 45 asthma patients from Beijing, China. The COPD group and the asthma group completed 148 and 180 lung function tests, respectively. We found that in COPD patients, for every 10-μg/m³ increase in PM₂.₅ exposure at lag2, the FEV₁, FVC and DLco decreased by −0.014 L (95% CI −0.025, −0.003), −0.025 L (95% CI −0.050, −0.003) and −0.089 mmol/min/kPa (95% CI −0.156, −0.023), respectively. There was also a decrease of −0.023 L/s (95% CI −0.042, −0.003) and −0.017 L/s (95% CI −0.032, −0.002) in MMEF at lag3 and lag03, respectively. In the asthma group, every 10-μg/m³ increase in PM₂.₅ exposure led to a reduction of −0.012 L (95% CI −0.023, −0.001), −0.042 L (95% CI −0.081, −0.003) and −0.061 L/s (95% CI −0.116, −0.004) in the FEV₁, FVC and PEF at lag3, respectively. Our findings suggest that PM₂.₅ exposure may primarily affect both airway function and lung diffusion function in COPD patients, and airway function in asthma patients.
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