A simple method for calculating the statistical power for detecting a QTL located in a marker interval

Hu, Z.; Xu, S.

A simple method for calculating the statistical power for detecting a QTL located in a marker interval

2008

Hu, Z. | Xu, S.

We developed a simple method for calculating the statistical power for detecting a QTL located in an interval flanked by two markers. The statistical method for QTL detection is assumed to be the Haley and Knott's simple regression method of interval mapping. This method allows us to answer one of the fundamental questions in designing a QTL mapping experiment: What is the minimum marker density required to detect a QTL explaining a certain heritable proportion of the phenotypic variance (denoted by h2) with a power gamma under a Type I error apha in an F2 or other mating designs with a sample size n? Computing the statistical power only requires the ability to evaluate a non-central F-distribution function and the inverse function of this distribution.

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