Effects of palm olein tocopherol and tocotrienol on lipid peroxidation, lipid profiles and glycemic control in non-insulin diabetes mellitus patients
Wan Nazaimoon, W.M. | Sakinah, O. | Gapor, A. | Khalid, B.A.K.
Refined palm oil, palm olein contains very low amount of vitamin-E (0.01%, w/w) as compared to its tocotrienol-rich extract, Palmvitee, which contains about 20% (w/w) of vitamin E. The effects of palm olein intake on serum lipid peroxides or malondialdehyde (MDA) levels, lipid profiles and glycemic control of 32 non-insulin dependent diabetes mellitus patients were compared to those of Palmvitee using a double-blind study. Patients took six 300 mg capsules of Palmvitee or palm olein daily for 60 days, underwent a washout period of 60 days, crossed-over in treatments and continued for another 60 days. Subjects who consumed Palmvitee showed significant increase in tocopherol and tocotrienol (p=0.004 and p=0.02 respectively), while subjects who consumed palm olein showed increase only in tocopherol levels (p=0.04). MDA levels on day 60 in patients given palm olein were inversely correlated with tocopherol levels (r=-0.644, p=0.007). MDA (mean +/- SEM) declined significantly (p<0.001) following palm olein or Palmvitee intake, 1.33 +/- 0.1 versus 1.07 +/- 0.07 and 1.47 +/- 0.09 versus 1.13 +/- 0.06 nmol/l respectively. The decline continued to be significant (p<0.001) during the washout period, then showed no further change thereafter. Neither palm olein nor Palmvitee caused significant changes in total cholesterol, HDL-chol, triglyceride, LDL-chol and glycemic control of the patients. This study showed that the small amount of vitamin E present in palm olein, was sufficient to significantly reduce lipid peroxidation and that increased intake of the vitamin, as in Palmvitee, did not cause further reduction in the peroxide levels.
Показать больше [+] Меньше [-]Ключевые слова АГРОВОК
Библиографическая информация
Эту запись предоставил National Agricultural Library